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Research Programs

Dr. Sakamuri ReddySakamuri V. Reddy, PhD
Professor & Director, Osteoclast Center
In 1988, Dr. Reddy obtained his PhD in Biochemistry from S.V. University, India. He then joined the University of Texas Health Science Center at San Antonio (UTHSCSA) as a postdoctoral fellow and advanced to the rank of associate professor in the department of medicine/hematology, UTHSCSA. He continued his career as an associate professor in the department of medicine/hematology-Oncology at the University of Pittsburgh. Dr. Reddy joined the Children's Research Institute at MUSC in July 2004. Dr. Reddy is a recipient Young Investigator Award and Paget's Foundation Award from the American Society of Bone and Mineral Research (ASBMR); NIH R01 Research Awards and Department of Defense (DOD) Medical Research Award. He is also the 2006 recipient of the Mitchell I Rubin Research Excellence Award in the department of pediatrics.

Dr. Reddy has been a member of several scientific organizations including San Antonio Cancer Research Institute, University of Pittsburgh Cancer Institute, ASBMR and a FASEB visiting professor. He has been a member of the Federation of the American Societies for Experimental Biology (FASEB) since 2004; Ad hoc member, publications committee, ASBMR (2006-2009). Dr. Reddy is also on the Faculty Tenure Committee, MUSC (2006-2009); Faculty Senate, MUSC (2005-2007). He has served on the International Relations Committee and Medical School Admission Committee for several years at the UTHSCSA, San Antonio. He has also served as a peer reviewer for several national and international scientific journals and funding agencies including the NIH and Department of Defense study sections in the field of arthritis and musculoskeletal disorders. Dr. Reddy has been a mentor for several postdoctoral trainees and taught the courses on Biomedical Foundation at the University of Pittsburgh and Bone Remodeling for Biomedical Graduate students at the MUSC. He served as ad hoc member in several NIH study sections which includes small business grants Review (SBIR/STTR); Tumor microenvironment (TME); Core centers for musculoskeletal diseases and Ruth L. Kirschstein National Research Service Awards for Individual Fellowships. He has also been reviewer for research proposals from international organizations such as Welcome Trust Foundation, British Medical Council, UK. He has been an editorial board member of the Journal of Bone and Mineral Research from 2009 to present. Dr. Reddy also served National Cancer Institute grant support panel to site visit National Comprehensive Care Cancer Center.

Dr. Reddy has published over 90 articles in peer reviewed journals in the field of bone biology and associated disorders. He has also been a reviewer for journals such as Cancer Cell; Developmental Cell, Biochemical Journal; Journal of Pathology (UK); and Endocrine Reviews. Dr. Reddy has received several patents including the Osteoclast Inhibitory Peptide-1 (OIP-1/hSca) which has therapeutic potential for osteoporosis disease. His research interests includes (i) Molecular aspects of osteoclast and osteoblast/stromal cell biology and gene regulation (ii) Osteopetrosis animal models, congenital bone fractures in spinal muscular atrophy; Paget's disease of bone and (iii) Cancer metastasis to bone. For more information, contact Dr. Reddy at 843-792-6807 or reddysv@musc.edu.

Dr. William RiesWilliam L. Ries DDS, PhD
Following his graduation from Alfred University in New York State with a BA degree in Biology, Dr. Ries obtained his DDS and PhD from the State University of NY at Buffalo. His PhD work investigated the cytochemistry and kinetics of cells isolated from periosteal bone surfaces in the adult rat. He further characterized enzymatic activity and nuclear incorporation kinetics in rat osteoclasts on periosteal bone surfaces at Virginia Commonwealth University in Richmond. While at Wake Forest University Medical Center, Winston-Salem, NC his studies moved on to the role of superoxide production in the resorption of bone by osteoclasts and how interference in oxygen radical formation could impair osteoclastic function. At MUSC, in addition to osteoclast biological studies, his expertise in bone histochemistry has been resourceful to clinical trials for the treatment of osteopetrosis and juvenile osteoporosis. For more information, contact Dr. Ries at 843-792-0805 or riesw@musc.edu.