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Department of Pediatrics : Academic Divisions : Hematology/Oncology : Hematology/Oncology Publications

Abstracts

Kalpatthi R, Ngwube A, Hlavacek A, Bowman M, Jackson SM, Imran H.Low Prevalence of Pulmonary Artery Hypertension in Children with Sickle Cell Anemia. The American Society of Pediatric Hematology Oncology 22nd Annual Meeting, April 22-25, 2009. San Diego, CA.

Jyothi V, Shatat I, Rackoff E, Disco D, Jackson SM, Kalpatthi R. Prevalence and Risk Factors of Microalbuminuria in Children with Sickle Cell Disease. The American Society of Pediatric Hematology Oncology 22nd Annual Meeting, April 22-25, 2009. San Diego, CA.

Ian Kane, Ibrahim Shatat, Betsy Rackoff, Deborah Disco, Sherron Jackson, Ram Kalpatthi. Clinical Events after Splenectomy in Children with Sickle Cell Anemia. Pediatric Ambulatory Society, May 2, 2009, Baltimore, MD.

Wooten-Blanks L, Kraveka JM. Subcellular Localization of the Dihydroceramide Desaturase as a Mechanism for Fenretinide Sensitivity. Poster Presentation at the Poster Presentation at the 5th International Charleston Ceramide Conference, 2009 March 11-14, Charleston, SC.

Escoto H, London WB, McGrady P, Li L, Wooten-Blanks L, Kraveka JM. Association of High Ceramide Levels with Unfavorable Neuroblastoma Risk Factors: A Report from the Children’s Oncology Group” Oral Presentation at the 5th International Charleston Ceramide Conference, 2009 March 11-14, Charleston, SC.

Rahmaniyan M, Curley RW, Li L, Hannun YA, Obeid LM, Kraveka JM. Characterization of the Dihydroceramide Desaturase Enzyme and the Effects of Fenretinde on Enzyme Activity In-Vitro” Oral Presentation at the 5th International Charleston Ceramide Conference, 2009 March 11-14, Charleston, SC.

Rahmaniyan M, Curley RW, Li L, Hannun YA, Obeid LM, Kraveka JM. Characterization of the Dihydroceramide Desaturase Enzyme and the Effects of Fenretinde on Enzyme Activity In-Vitro” Poster Presentation at the 100th American Association for Cancer Research Meeting, 2009 April 17- 22 Denver, CO.

Escoto H, London WB, McGrady P, Kraveka JM. Association of High Ceramide Levels with Unfavorable Neuroblastoma Risk Factors: A Report from the Children’s Oncology Group” Poster Presentation at the 100th American Association for Cancer Research Meeting, 2009 April 17- 22 Denver, CO.

Escoto H, London WB, McGrady P, Kraveka JM. Association of High Ceramide Levels with Unfavorable Neuroblastoma Risk Factors: A Report from the Children’s Oncology Group” Poster Presentation at Presentation at the 21st Annual Meeting of the Society of Pediatric Hematology Oncology, 2009 April 22-25 San Diego, CA.

Kraveka JM. Update on the results of ANHL0131” Oral Presentation at Joint Children’s Oncology Group/ European Intergroup for Childhood Non-Hodgkin Lymphoma (COG-EICNHL) Meeting 2009 June 10, Frankfurt, Germany.

Kraveka JM, Weitzman S, Smith L, Lynch JC, Chang M, Kinney M, Perkins S, Laver J, Gross TG and Weinstein H. Advanced-Stage Anaplastic Large-Cell Lymphoma in Children and Adolescents: Results of ANHL0131, a Randomized Phase III Trial with Standard APO (Doxorubicin, Prednisone, Vincristine) Versus Consolidation with a Regimen Including Vinblastine: A Report from the Children’s Oncology Group” Oral Presentation at the Third International Symposium on Childhood Adolescent, and Young Adult Non-Hogkins Lymphoma, 2009 June 11-13, Frankfurt, Germany.

Lewis JA, Jenrette JM, Watkins JM, Kraveka JM, Hudspeth MP. Total Lymphoid Irradiation for the Treatment of Refractory Bronchiolitis Obliterans following Allogeneic Hematopoietic Stem Cell Transplantation. 2010 American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplantation Research Meeting, Orlando, FL.

Lewis JA, Ragucci DP, Nista EJ, Hudspeth MP. Performance Characteristics of Galactomannan Enzyme Immunoassay in Pediatric Allogeneic HSCT Recipients. 2010 American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplantation Research Meeting, Orlando, FL.

Kraveka JM, Weitzman S, Smith LM, Lynch J, Chang M, Kinney MC, Perkins S, Laver J, Gross TG, Weinstein H. ”Advanced-stage Anaplastic Large-cell Lymphoma in Children and Adolescents: Results of ANHL0131, A Report from the Children’s Oncology Group” J Clin Oncol 28:7s, 2010 (suppl; abstr 9511)

Lim MS, Pulford K, Ait-Tahar K, Patel SD, Kinney MC, Perkins SL, Anderson, JR, Smith L, Cairo MS, Weitzman S, Gross TG, Kraveka, JM “The Autoantibody Response to ALK In Pediatric Anaplastic Large Cell Lymphoma: A Children’s Oncology Group Report” Blood (ASH Annual Meeting Abstracts), Nov 2010; 116: 4130.

Sholler-Saulnier GL, Kahn J, Ferguson W, Bergendahl G, Currier E, Lenox S, Bond J, Roberts W, Mitchell D, Eslin D, Kraveka J, Kaplan K, Parikh N, Malempati, Hanna G, Kamen B, Webb C “A pilot trial testing the feasibility of using molecular-guided therapy in patients with refractory or recurrent neuroblastoma” In: Proceedings of the 102nd American Association for Cancer Research Meeting, 2011 April 2-6 Orlando, FL; Philadelphia (PA): AACR; 2009. Abstract # 3942

Lorenzana AN,  Aslakson C, Sawaf H, Kinney M, Perkins P , Anderson A, Smith LM, Cairo MS,  Weitzman S, Gross TG,  Kraveka JM, Lim MS “Serum Levels of Soluble CD30 in Pediatric Anaplastic Large Cell Lymphoma (ALCL): A Children’s Oncology Group Report”  Ann Oncol 22(suppl 4)  June 2011 (abstr 270)
 
Clonal Evolution is a Stronger Predictor than Disease Status of Disease-Free Survival after Pediatric HSCT. Michelle P. Hudspeth MD, Codruta Chiuzan, Elizabeth Garrett-Mayer PhD, Elizabeth Nista BA, Jana Robertson MD, and Daynna Wolff PhD. Poster presentation 2011 American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplantation Research Meeting. Honolulu, HI

Folinic Acid Rescue Increases Ability to Deliver Full Course of Methotrexate GVHD Prophylaxis for Pediatric HSCT Recipients. Michelle P. Hudspeth MD, Travis Heath PharmD, Codruta Chiuzan, Elizabeth Garrett-Mayer PhD, Elizabeth Nista BA, Lori Burton PNP, and Dominic Ragucci PharmD. Poster presentation 2011 American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplantation Research Meeting. Honolulu, HI

American Society of Hypertension Annual Scientific Meeting and Exposition. De Angulo GA, Adams RJ, Eunsil Y, Kwiatkowski JL, Xavier AC, Debenham E, Peterson JA, Lackland DT. Systolic and diastolic blood pressures among sickle cell patients. New York, NY. 2011

National Predoctoral Clinical Research Training Meeting. De Angulo GA, Adams RJ, Kwiatkowski JL, Xavier AC, Lackland DT. Analysis of blood pressure and hematological variables among sickle cell patients. St Louis, MO. 2011

Medical Student Research Symposium. Wayne State University School of Medicine. Herman SD*, Xavier AC, Strathdee LA, Mohamed AN, Taub JW. Are the presenting symptoms of childhood acute lymphoblastic leukemia linked to differences in biological characteristics? Detroit, MI. 2010

American Society of Hematology Annual Meeting. Chen Q, Fassinger N, Thomas R, Xavier AC, Ge Y, Matherly LH, Taub JW. Altered folate metabolism may be linked to the development of acute lymphoblastic leukemia in African American children. Blood 114 (ASH Annual Meeting Abstract # 4118) 2009

American Association for Cancer Research Annual Meeting. Xavier AC, Edwards H, Xie C, Dombkowski AA, Buck SA, Matherly LH, Ge Y, Taub JW. The role of short form of GATA1 protein in Down syndrome biology and therapy. Denver, CO. 2009

Kalpatthi R, Ngwube A, Hlavacek A, Bowman M, Jackson SM, Imran H.Low Prevalence of Pulmonary Artery Hypertension in Children with Sickle Cell Anemia. The American Society of Pediatric Hematology Oncology 22nd Annual Meeting, April 22-25, 2009. San Diego, CA.

Jyothi V, Shatat I, Rackoff E, Disco D, Jackson SM, Kalpatthi R. Prevalence and Risk Factors of Microalbuminuria in Children with Sickle Cell Disease. The American Society of Pediatric Hematology Oncology 22nd Annual Meeting, April 22-25, 2009. San Diego, CA.

Ian Kane, Ibrahim Shatat, Betsy Rackoff, Deborah Disco, Sherron Jackson, Ram Kalpatthi. Clinical Events after Splenectomy in Children with Sickle Cell Anemia. Pediatric Ambulatory Society, May 2, 2009, Baltimore, MD. Wooten-Blanks L, Kraveka JM. Subcellular Localization of the Dihydroceramide Desaturase as a Mechanism for Fenretinide Sensitivity. Poster Presentation at the Poster Presentation at the 5th International Charleston Ceramide Conference, 2009 March 11-14, Charleston, SC.

Escoto H, London WB, McGrady P, Li L, Wooten-Blanks L, Kraveka JM. Association of High Ceramide Levels with Unfavorable Neuroblastoma Risk Factors: A Report from the Children’s Oncology Group” Oral Presentation at the 5th International Charleston Ceramide Conference, 2009 March 11-14, Charleston, SC.

Rahmaniyan M, Curley RW, Li L, Hannun YA, Obeid LM, Kraveka JM. Characterization of the Dihydroceramide Desaturase Enzyme and the Effects of Fenretinde on Enzyme Activity In-Vitro” Oral Presentation at the 5th International Charleston Ceramide Conference, 2009 March 11-14, Charleston, SC.

Rahmaniyan M, Curley RW, Li L, Hannun YA, Obeid LM, Kraveka JM. Characterization of the Dihydroceramide Desaturase Enzyme and the Effects of Fenretinde on Enzyme Activity In-Vitro” Poster Presentation at the 100th American Association for Cancer Research Meeting, 2009 April 17- 22 Denver, CO.

Escoto H, London WB, McGrady P, Kraveka JM. Association of High Ceramide Levels with Unfavorable Neuroblastoma Risk Factors: A Report from the Children’s Oncology Group” Poster Presentation at the 100th American Association for Cancer Research Meeting, 2009 April 17- 22 Denver, CO.

Escoto H, London WB, McGrady P, Kraveka JM. Association of High Ceramide Levels with Unfavorable Neuroblastoma Risk Factors: A Report from the Children’s Oncology Group” Poster Presentation at Presentation at the 21st Annual Meeting of the Society of Pediatric Hematology Oncology, 2009 April 22-25 San Diego, CA.

Kraveka JM. Update on the results of ANHL0131” Oral Presentation at Joint Children’s Oncology Group/ European Intergroup for Childhood Non-Hodgkin Lymphoma (COG-EICNHL) Meeting 2009 June 10, Frankfurt, Germany.

Kraveka JM, Weitzman S, Smith L, Lynch JC, Chang M, Kinney M, Perkins S, Laver J, Gross TG and Weinstein H. Advanced-Stage Anaplastic Large-Cell Lymphoma in Children and Adolescents: Results of ANHL0131, a Randomized Phase III Trial with Standard APO (Doxorubicin, Prednisone, Vincristine) Versus Consolidation with a Regimen Including Vinblastine: A Report from the Children’s Oncology Group” Oral Presentation at the Third International Symposium on Childhood Adolescent, and Young Adult Non-Hogkins Lymphoma, 2009 June 11-13, Frankfurt, Germany.

Lewis JA, Jenrette JM, Watkins JM, Kraveka JM, Hudspeth MP. Total Lymphoid Irradiation for the Treatment of Refractory Bronchiolitis Obliterans following Allogeneic Hematopoietic Stem Cell Transplantation. 2010 American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplantation Research Meeting, Orlando, FL.

Lewis JA, Ragucci DP, Nista EJ, Hudspeth MP. Performance Characteristics of Galactomannan Enzyme Immunoassay in Pediatric Allogeneic HSCT Recipients. 2010 American Society for Blood and Marrow Transplantation/Center for International Blood and Marrow Transplantation Research Meeting, Orlando, FL.

Journal Articles

Idkowiak-Baldys J, Apraiz A, Li L, Rahmaniyan M, Clarke CJ, Kraveka JM, Asumendi A, Hannun YA. Dihydroceramide desaturase activity is modulated by oxidative stress. Biochem J. 2010 Mar 29;427(2):265-74

Rahmaniyan M, Curley RW Jr, Obeid LM, Hannun YA, Kraveka JM. Identification of Dihydroceramide Desaturase as a Direct in vitro target for Fenretinide. J Biol Chem. 2011 Jul 15;286(28):24754-64. Epub 2011 May 4

Hudspeth MP, Brown E, Ragucci D, Dixon T, Turner R. Severe pruritus and hypothermia as the primary manifestations of Human Herpes Virus-6 encephalitis after pediatric cord blood transplantation. Bone Marrow Transplantation. 2011, in press.
 
Post GR, Lewis JA, Hudspeth MP, Caplan MJ, Lazarchick J.  Disseminated Neuroendocrine Carcinoma in a Pediatric Patient: A Rare Case and Diagnostic Challenge.  Journal of Pediatric Hematology/Oncology.  2011, in press.
 
Xavier AC, Ge Y, TaubJW. Down syndrome and malignancies: a unique relationship. J Mol Diagn 2009; 11(5): 371-380.

Xavier AC, Taub JW. Acute leukemia in children with Down syndrome. Haematologica 2010; 95(7): 1043-45.

Xavier AC, Ge Y, Taub JW. Unique clinical and biological features of leukemia in Down syndrome children. Exp Reviews of Hematol 2010; 3(2): 175-86.
 
Barker JN, Doubrovina E, Sauter C, Jaroscak JJ, Perales MA, Doubrovin M, Prockop SE, Koehne G, O'Reilly RJ Successful treatment of EBV-associated posttransplantation lymphoma after cord blood transplantation using third-party EBV-specific cytotoxic T lymphocytes. Blood. 2010. 23. 5045-9.

Dvorak, C.C., Gilman, A.L., horn, B., Jaroscak, J., Dunn, E.A., Baxter-Lowe, L.A., Cowan, M.J. Clinical and immunologic outcomes following haplocompatible donor lymphocyte infusions. Bone Marrow Transplantation. 2009. 1-8. 

Hudspeth MP, Joseph S, Holden KR. A Novel Mutation in Type II Methemoglobinemia. J Child Neurol. 2009: 2010 Jan;25(1):91-3.

Hudspeth MP, Hill TN, Lewis JA, Van Meter E, Ragucci D. Post-hematopoietic stem cell transplant immunization practices in the Pediatric Blood and Marrow Transplant Consortium. Pediatric Blood and Cancer. 2010 Jul 1;54(7):970-5.

Brown E, Hebra A, Jenrette J, Hudspeth MP. Successful treatment of late, recurrent Wilms' tumor with high dose chemotherapy and autologous stem cell rescue in third complete response. Journal of Pediatric Hematology/Oncology. In press.

Faculty Involvement at the National Level

Dr. Kraveka

  • Study Chair /Principal Investigator for Children’s Oncology Group: ANHL0131: A Phase III Trial of Treatment of Advanced-Stage Anaplastic Large Cell Lymphoma (ALCL) with Standard APO (Doxorubicin, Prednisone, Vincristine) versus Consolidation with a Regimen Including Vinblastine
  • Study Committee Member of the Children’s Oncology Group ANBL0532: A Phase III Randomized Trial of Single versus Tandem Myeloablative Consolidation Therapy for High-Risk Neuroblastoma
  • Member of the Children’s Oncology Group Neuroblastoma Clinical and Biological Risk Factors Task Force
  • Institutional Principal Investigator for the Neuroblastoma and Medulloblastoma Translational Research Consortium

Dr. Hudspeth

  • Committee Member for the Pediatric Blood and Marrow Transplant Consortium Supportive Care Strategy Group
  • Committee Member for the Pediatric Blood and Marrow Transplant Consortium Oncology Strategy Group
  • Center for International Blood and Marrow Transplant Research, GVHD Working Committee
  • Center for International Blood and Marrow Transplant Research, Pediatric Cancer Working Committee
  • Center for International Blood and Marrow Transplant Research, Immune Deficiencies/Inborn Errors of Metabolism Working Committee

Both Dr. Kraveka and Dr. Hudspeth serve as ad-hoc reviewers for several journals.