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Department of Pediatrics : Academic Divisions : Emergency Medicine : Resident Manual : Transfusion Guidelines : Plasma & Cryoprecipitate

Product Parameters:

  • Frozen plasma: stored -18°C for 1 year; volume ~250mL
  • Cryoprecipitate: stored frozen -18°C for 1 year; each unit contains ~440mg fibrinogen in a volume of 10-30 mL

Indications:

  • Plasma: PT or aPTT > 1.5 times normal due to a deficiency of clotting factors (do not use when coagulopathy due to a deficiency of factors VIII or IX alone)
  • Cryoprecipitate: fibrinogen

Compatibility:

  • Plasma and cryoprecipitate should ABO compatible with patient's red cells

Dosing and Response:

  • Plasma: 10-15mL/kg; should ?factor levels 15-20%
  • Cryoprecipitate: 1 unit/10kg; should fibrinogen 60-100mg/dL

Clinical considerations:

  • Irradiation (Graft versus Host Disease risk):
    • Need for irradiation controversial


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