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Department of Pediatrics : Academic Divisions : Emergency Medicine : Resident Manual : Transfusion Guidelines : Granulocytes

Product Parameters:

  • 1.0 x 109 neutrophils/unit
  • Must be ordered 24-48 hours before need
  • Shelf-life 24 hours (transfuse as soon as possible)
  • Will be provided before infectious disease testing completed


  • Documented infection
  • Failed trial of antibiotics
  • Granulocyte count < 500/mm3
  • Neonatal sepsis


  • Must be ABO compatible (same as red cell transfusion)

Dosing and Response:

  • 15 mL/kg; repeat daily
  • Daily until clinical improvement (5-7 days)
  • Most effective in bacterial infections; less effective in fungal infections

Clinical considerations:

  • Irradiation (Graft versus Host Disease risk):
    • Same as for red cells

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