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Thrombocytopenia

Normal platelet count is 150,000-400,000/cmm (including premies and newborns)

Etiology:

Increased destruction (most common)

  • Immune
  • Primary: Idiopathic thrombocytopenic purpura (ITP) [most common & a diagnosis of exclusion]
  • Secondary: Drugs (heparin), SLE, Common Variable immunodeficiency, Evans syndrome
  • Non-immune
  • TTP/HUS
  • DIC
  • Drugs: anticonvulsants (valproate)

Decreased production

  • Infection/sepsis
  • Malignancy/chemotherapy
  • Aplasia
  • Thrombocytopenia-absent radiai syndrome (TAR)
  • Congenital amegakaryocytic thrombocytopenia

Sequestration

  • Hypersplenism
  • Kasabach-Meritt syndrome (kaposiform hemangioendothelioma with DIC)


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